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As with any supplement, periodic breaks (three months on, one month off) are a reasonable precautionary approach, particularly for individuals with no confirmed deficiency or elevated oxidative stress markers

By the same token, because there is not an FDA-approved version out there, theres no competition risk

Only about half of the vitamin B12 ingested from food sources is absorbed into the body, and this reduces further with age

Association of+1245 A/G MT1A and-209 A/G MT2A polymorphysms with coronary artery disease and diabetes mellitus in Bulgarian cohort

Some people can tolerate twice-daily use after their skin adjusts, but always listen to your skin and reduce frequency if you experience irritation