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3 RGN-259 Phase 3 Trial in Neurotrophic Keratopathy Sosne et al., International Journal of Molecular Sciences (2022) This Phase 3 randomized, placebo-controlled, double-masked clinical trial evaluated topical 0.1% RGN-259 (full-length recombinant T4 ophthalmic solution) in patients with neurotrophic keratopathy

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Other potential causes of B12 deficiency include: Gastritis Digestive diseases, such as Crohns disease and celiac disease Gastrointestinal surgery, such as gastric bypass Alcohol use Transcobalamin II deficiency, a rare genetic disorder that impairs the transport of vitamin B12 in the body Autoimmune disorder Complications/related conditions Is B12 deficiency serious or dangerous

Dietary changes can help, but severe deficiency or certain health issues might need supplements

Modulating Fibrosis: It prevents excessive scar tissue formation, which can trap nerves and prevent them from reconnecting