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DOI: 10.1097/JU.0000000000003999

Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH-S-transferases

Importantly, the thioredoxin pathway has been considered to be the primary reductive system, with glutathione seen as having a back-up or auxiliary role [3840]

RNA-Seq will be performed on these samples to further validate the translatability of our findings

Other thiols, including biological ones such as cysteine and GSH, were also shown to cleave persulfide and to sustain Fe-S cluster synthesis, thus raising the possibility that these thiol-based reactions could be physiologically relevant (Parent et al., 2015