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Alternative approaches with the inversed configuration have been developed in which gRNAs with different sequences are used as barcodes, and a CRISPRa reporter containing a target sequence is introduced for barcode-specific fluorescent reporter activation 30,31

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Pediatric pharmacokinetics and long-term safety require clarification, particularly for polyphenols and carotenoids with intrinsically low oral bioavailability and potential interactions with conventional medications like antipsychotics or stimulants (Hendouei et al., 2020