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Description

Frank, M., Thumer, L., Lohse, M

doi: 10.1038/s41586-023-06017-4 344 SongX.ChenJ.HouZ.XieN

Semaglutide GLP-1 helps with appetite control by mimicking the action of the naturally occurring GLP-1 hormone, which plays a crucial role in regulating hunger and food intake

By blocking NNMT activity, the compound preserves nicotinamide availability for the NAD+ salvage pathway, leading to 1.2- to 1.6-fold increases in intracellular NAD+ concentrations