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However, rare point mutations in the TBX1 gene indicate that TBX1 haploinsufficiency is responsible for most of the physical abnormalities associated with 22q11.2DS, and they have also been associated with attention deficits, mild mental retardation, learning difficulties, developmental delay, Aspergers syndrome, and depression (2, 3, 4, 5)

Moreover, small prospective trials demonstrated that metformin reduces left ventricular (LV) mass and improves diastolic function and myocardial energetics, suggesting favorable effects on cardiac remodeling central to DCM pathophysiology (Mohan et al., 2019)

19 HU has also been associated with an increased risk of developing hypertension, and a chronic phase of microvascular injury is known to occur after prolonged periods of HU

Its chemical and physical properties make it appropriate as a probe for lipid peroxidation

Nature 579, 270273