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In a nutshell, vitamin B 12 is a micronutrient essential to human health

The role of endothelial cell injury and platelet response in its genesis

Method The local tolerance upon subcutaneous administration of the co-formulations described in table 23a and 23b was studied in 8 live minipigs, by evaluation of the resulting skin lesions 6 days (necropsy) after subcutaneous administration of sample sizes of 750pl using syringes equipped with 25 G sized needles and 5mm stoppers

B12 deficiency triggers this through two mechanisms: Impaired red blood cell production reduced oxygen delivery to follicles Impaired DNA synthesis disrupted cell division in rapidly proliferating follicle matrix cells Clinical studies confirm lower serum B12 levels in patients presenting with telogen effluvium, and case studies document hair regrowth following B12 correction

If this occurs, the symptoms are typically temporary and should resolve within a day or two