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Interestingly, animals like salamanders and axolotl are able to regenerate entire limbs, and this regenerative process is driven primarily by hematopoietic and myeloid stem cells, which in the human is the equivalent of bone marrow stem cells that drive mesenchymal cell lineages of ligament, cartilage, muscle, bone, and connective tissues [52]

Moreover, the PGC-1/ERR axis directly promotes the expression of key fusion and fission genes

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They reflect pharmacokinetic logic for research use under appropriate oversight