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In contrast, the Nrf2 pathway serves a protective role by activating antioxidant response elements (ARE) and upregulating genes encoding antioxidant enzymes (Li X

Similar content being viewed by others Introduction Knee osteoarthritis (KOA) is the most common form of arthritis and is characterized by the loss of structure in the articular cartilage, remodeling of the subchondral bone, generation of synovial inflammation, and osteophyte formation [1]