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Figure 20-2 The mucociliary apparatus represents the first line of defense for pathogens entering the respiratory tract

In order to demonstrate that the 127 gene signature is related to regional emphysema severity within individuals and not to differences between donors and COPD patients or to differences in levels of emphysema between COPD patients, we repeated the same statistical analysis while only including the five COPD patients with emphysema and standardizing the Lm measurements within each patient core to a mean of zero and a standard deviation of one (Z-score)

Statistical analyses The statistical analyses were performed by the SPSS Statistics 19 software (IBM, USA), using descriptive statistics and one-way ANOVA for dependent samples with the Bonferroni post hoc test

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