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The impairment of antioxidant defense mechanisms leaves ROS levels unregulated, thus favoring a condition in which macromolecular targets can be readily attacked by the excess ROS [35, 36, 39, 40]

An otherwise solid-unit will fail dramatically if you expect it to do too much work

Post-acute COVID-19 syndrome, also known as post-COVID syndrome, long COVID, persistent long COVID, or post-acute COVID sequelae (PACS), is a pathological disease characterized by persistent physical, medical, and cognitive sequelae after acute COVID-19 [179]

After adjusting for potentially influential factors, these odds were, respectively, 12%, 23%, 40%, and 21% higher

More enforcement is no doubt needed