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Immunostaining for glial fibrillary acidic protein (GFAB, a marker for astrocytes) and ionized calcium-binding adapter molecule 1 (Iba-1, a marker for microglia) indicated reduced astrocyte and microglia activation in both striatum and substantia nigra

2020;158(8):2139-2149.e14

The administration route is another factor that needs to be optimized to ensure the effectiveness and safety of plant bioactive compounds

J Hepatol 40:4046 Medici V, Virata MC, Peerson JM, Stabler SP, French SW, Gregory JF 3rd, Albanese A, Bowlus CL, Devaraj S, Panacek EA, Richards JR, Halsted CH (2011) S -adenosyl-l-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial