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Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR)

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[59] reported that individuals at stages IIIV of chronic kidney disease exhibit significantly reduced urine levels of S-adenosylmethionine and SAM/S-adenosylhomocysteine ratio, as well as a decreased cysteine/homocysteine ratio in blood plasma in comparison to patients at stage II of CKD

Hematology 2014, the American Society of Hematology Education Program Book