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Graphical Abstract Similar content being viewed by others Introduction In less than two decades since Yamanaka and colleagues first published a protocol to reprogram somatic cells back to a pluripotent state using key transcription factors such as Oct4, Sox2, Klf4, and c-Myc, the field of human induced pluripotent stem cells (hiPSCs) has undergone remarkable advancements [1, 2]

In comparison to skeletal muscles, only a small amount of total creatine is found in the brain, however, the brain is an energetically demanding organ and accounts for approximately 20% of body energy consumption despite accounting for only 2% of total body mass (Forbes et al., 2022)

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) provided funds for research in the lab of Bruce Morgan through the grant MO 2774/61 project number 505680640

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