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Ramalho-Santos, J., Amaral, S

During chronic demyelination, oligodendrocytes rely on their own cholesterol synthesis for remyelination

Reducing USP9X lowered the expression of BMAL1 target genes PER2 and CRY1 in mouse neuroblastoma cells, but in U2OS cells, knockdown only slightly reduced rhythm amplitude without changing the period (Zhang et al., 2018)

A final word from Dr Webster Acanthosis nigricans is common, often misunderstood, and frequently dismissed as just pigmentation. In reality, it can be a valuable clinical clue that allows us to intervene earlier, protect long-term health, and improve both skin and metabolic outcomes.

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