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The combination protocol increases the number of dose escalation events (since you are titrating two compounds), which may mean more frequent but generally mild headaches

Abbreviations AID: Automated insulin delivery CGM: Continuous glucose monitoring DKA: Diabetic ketoacidosis GMI: Glucose management indicator MDI: Multiple daily injections SEP: Socioeconomic position vMWMT: Virtual Morris water maze task References Jacobson AM, Ryan CM, Braffett BH et al (2021) Cognitive performance declines in older adults with type 1 diabetes: results from 32 years of follow-up in the DCCT and EDIC Study

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents: To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions

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