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In terms of molecular mechanism, we also discussed the role of endogenous (enzymatic, and non-enzymatic) and exogenous antioxidants (vitamins, plant-derived and other small molecules), including ascorbic acids, -carotene, -tocopherol, -lipoic acid, coenzyme Q10, melatonin, and flavonoids (quercetin, luteolin, kaempferol, epicatechin, catechin, daidzein, genistein, and rutin, etc.) in scavenging of ROS

Sweet potatoes help retain vitamin A, sunflower seeds are rich in vitamin E, and yellow peppers are rich in vitamin C

Future studies examining protein expression and activation, such as Western blot analysis of phosphorylated Akt and PI3K, are warranted to confirm the mechanistic effects of DHA and Vildagliptin on the SIRT1/Akt/PI3K pathway in insulin-sensitive tissues such as skeletal muscle, liver, and adipose tissue to strengthen mechanistic and translational relevance

NK cells associate with ALS in a sex- and age-dependent manner

Nutrition should support muscle preservation