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In UK primary care, patients with a B12 above 1,000 pmol/L had a one-year cancer incidence rate ratio of 4.72 compared with those in the reference range

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First, hyperhomocysteinemia detected only in the fasting state (approximately 23% of patients), which might mainly result from an inhibition of the homocysteine remethylation pathway (folate, cobalamin, or functional methionine synthase deficiencies or thermolabile MTHFR mutation), and which increases the cardiovascular risk 1.6-fold

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