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36 AICAR and metformin, two well-known AMPK agonists, were reported to inhibit osteogenic differentiation and relieve pain level in mouse and rhesus macaques models

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In chronic MPTP-treated primates, clioquinola metal-chelating agentreduces SN iron and ROS levels, attenuates 4-HNE accumulation, and protects DA neurons (274), indicating that iron chelation can serve as a viable strategy for PD intervention by targeting ferroptosis

Aberrant SUMOylation is a feature of human aging and disease Although SUMOylation is well understood to play an essential role in the CNS, its involvement in human aging and neurodegenerative diseases remains largely elusive