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PMID: 37890360 SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation

high-fat diet feeding diminished fatty acid -oxidation, as indicated by remarkably decreased hepatic mRNA levels of Carnitine palmitoyltransferase 1 A ( Cpt1a ) , Solute carrier family 25 member 20 ( Slc25a20 ) , Acyl-CoA dehydrogenase, medium-chain (Acadm), Acyl-CoA dehydrogenase, short-chain (Acads) , and Peroxisome proliferator-activated receptor alpha ( Ppara ) in MASLD mice (Fig

On the other hand, mTOR also participates in mitochondrial quality control and coordinates the degradation of defective organelles via autophagy and mitophagy

The G6PD phosphorylation is positively correlated with G6PD-SRC-GSTP1 complex in ER/PR positive type or HER negative types of breast cancer Molecular sub-typing of breast cancer heavily relies on the expression patterns of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER) [50]

doi: 10.3389/fncel.2024.1371213 15 GalganoM.ToshkeziG.QiuX.RussellT.ChinL.ZhaoL.-R