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This agent has a lower affinity for Zn(II) than the previously used chelator PAR

These mechanisms exacerbate and compound tissue dysfunction involving cardiovascular, immune, metabolic, endocrine, coagulation, and thermoregulatory pathways, and are responsible for the systemic effects and multi-organ failure [5, 16, 19,20,21]

And, because the symptoms of STXBP1 overlap with a lot of other neurodevelopmental disorders (seizures, developmental delay, intellectual disability, motor issues, etc.), we can't use symptoms to accurately identify STXBP1 patients

18 The most bioavailable forms of B12 are methylcobalamin, hydroxocobalamin, and adenosylcobalamin

Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review