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The goal is to restore normal pulsatile GnRH release, which produces coordinated LH and FSH secretion, which drives follicular maturation and ovulation

Turner DA, Adamson DC (2011) Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism

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The IGF-1 MSIA-SRM provides a linear dynamic range spanning 11,500 ng/mL ( Figure 3 ), enabling a single assay to quantify IGF-1 over its biologically relevant concentrations and the ability to quantify as little as 5 femtomoles of IGF-1 from 40 mL human plasma