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Kendrick T, et al

Inhibition of mTORC1 pathway by rapamycin was without effect on the ISR, suggesting that mTORC1 signaling does not contribute to the ISR in this setting

12A and B)

Lyophilised IGF-1 LR3 tolerates short-term exposure to ambient temperatures better than reconstituted solutions, but anything beyond 72 hours at 25C or 24 hours above 30C likely caused measurable degradation