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The availability of epinephrine nasal spray may reduce barriers to rapid treatment of anaphylaxis. Neffys approval is based on four studies in 175 healthy adults, without anaphylaxis, that measured epinephrine concentrations in the blood following administration of the nasal spray or approved epinephrine injection products

In one study, TDLNs from patients who progressed on immune checkpoint inhibition had higher Treg frequencies than those from responders, raising the possibility that nodal immune composition could help predict benefit from checkpoint blockade

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