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A 2023 systematic review and meta-analysis of randomized trials by Squires et al

It may prevent the binding of the FOXO4 protein with p53, allowing p53 to bind with DNA and trigger apoptosis in senescent cells

Within the brain, DSIP is particularly abundant in the hypothalamus, hippocampus, and limbic regions, where it interacts with multiple peptide and non-peptide mediators, including corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), and melanin-concentrating hormone (MCH)