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Disease, affected genes, type of model, patient-specific alterations described in the model and therapies tested or suggested are described

If you dose at 9am but don't eat until noon, the peak effect is wasted on an empty stomach

Elsevier Ireland Ltd

In oncology trials, 4450% of patients experienced grade 3 or 4 thrombocytopenia 33,34

It is not yet known whether PCBPs mediate ferritin iron loading in the intestinal enterocyte, but if enterocytes do rely on PCBPs, they may also serve as a limiting component for body iron accrual by directing and loading the metal to ferritin