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Study Selection Inclusion criteria were set to cohort studies, RCTs, meta-analyses, and systematic reviews

(2017) 32:377391.e9

Notably, studies have demonstrated that in diabetic conditions, depletion of the mitochondrial thioredoxin-2 (Trx2)/GSH system in db/db mice disrupts redox homeostasis, resulting in lipid peroxidation of the mitochondrial membrane and impaired activity of respiratory chain complexes

This is accompanied by enhanced SCFA production, increased GLP-1 secretion, improved insulin sensitivity, better intestinal barrier integrity, and reduced systemic inflammation (Birkeland et al., 2020)

The peptide earned its name from early research demonstrating protective effects across multiple organ systems