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Furthermore, the link between astrocytic metabolism and neurodegeneration is gaining traction: during brain aging or degenerative processes, the efficiency of astrocyte-neuron metabolic couplingcritical for glutamate homeostasis via transporters like GLT-1 and GLASTdeclines, leading to reduced glutamate clearance, extracellular accumulation, and NMDA receptor-mediated excitotoxicity, which drives neuronal dysfunction

Science 367 , 205210 (2020)

*Correspondence: Jisen Zhang, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Plant Development and EvoDevo, a section of the journal Frontiers in Plant Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Cho SK, Pedram A, Levin ER, Kwon YJ

PPT1 inhibition induced lysosomal lipid peroxidation (LLP), which led to lysosomal membrane permeabilization and cell death that could be reversed by the antioxidant N-acetylcysteine (NAC) but not by other lipid peroxidation antioxidants