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Several haplotypes of OCTN1 promoter have shown reduced transcriptional activities by a degree of 22.9%-44.6% [122]

Karkucinska-Wieckowska, A

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doi: 10.1111/SPOL.12675 220 SaunesISVrangbkKByrkjeflotHJervelundSSBirkHOTynkkynenLKet al

In essence, PD pathogenesis involves a combination of excessive iron influx and impaired iron efflux, culminating in net iron accumulation within vulnerable Substantia Nigra pars compacta (SNc) neurons