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Inverse variance weighting (as main analysis), weighted median estimate, robust adjusted profile score, MR-Egger, and MR-PRESSO (sensitivity analyses) were performed to calculate causal estimates

Each diet was administered one week before the start of DSS administration

In vivo , FTO knockdown significantly elevates YTHDF2 expression in the striatum of PD mice, inhibits m 6 A demethylation of BAP1 and reduces BAP1 expression, upregulates SLC7A11 expression, decreases -Syn, MDA, Fe 2+ , and 4-HNE levels, suppresses neuronal ferroptosis and disruptions in the amino acid antioxidant system, and promotes dopaminergic neuronal survival in PD mice (Li et al., 2025c)

[Google Scholar] 54.Chen CY, Lin LC, Yang WF, et al

the crude product (180 g) thus obtained was purified by Flash column chromatography [2.5 Kg silica gel, Using the following eluents i) column packed with 6 L of 0.1% NEt 3 in DCM