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Subsequently, histone deacetylase HDAC3 enhances the level of H4K12 lactylation, promoting the transcription of newly formed SASP factors and exacerbating atherosclerosis [190]

Funding The authors did not receive support from any organisation for the submitted work

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Elevated intracellular sorbitol also provides excess nicotinamide adenine dinucleotide (NADH) to the mitochondrial electron transport chain, which is a substrate for complex I (substrate for complex I) in mitochondria and closely affects mitochondrial function and cellular energy metabolism

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