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Gene Therapy in Thoracic Tumors

These methods reveal that astrocyte Ca 2+ elevations, triggered by mechanical or electrical stimuli, drive glutamate release to modulate neuronal activity via ionotropic (iGluR) or metabotropic (mGluR) receptors, as seen in hippocampal slices where astrocyte Ca 2+ waves inhibit or enhance presynaptic neurotransmission, highlighting context-dependent metabolic coupling in physiological and stress conditions (Chen et al., 2023)

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