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MTHFR mutations have been linked to various health concerns, including: Cardiovascular disease risk due to high homocysteine Mood disorders such as depression, anxiety, and irritability Immune dysfunction and increased inflammation Hormonal imbalances affecting menstrual cycles and fertility Reduced glutathione production, impacting detoxification Increased risk for autoimmune conditions DNA and RNA synthesis abnormalities Recognizing these risks allows for proactive management through lifestyle and nutritional support

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Finally, the application prospects and challenges of nano-STING agonists-based immunotherapy are also discussed from the perspective of clinical translation

We also performed this experiment treating cells with 0.04 mol L 1 or 0.16 mol L 1 IAA for 48 h

Liver puncture was not performed for the patient due to coagulation dysfunction