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Pei et al., 2023)

Patients assigned to tirzepatide showed a 20.9% BW loss after 36 weeks with an additional 5.5% reduction after 52 weeks, while those who switched to placebo experienced a 14% weight regain, confirming the findings from STEP 4 supporting the chronicity of obesity and the need for continuous treatment

Many patients notice improved energy levels and reduced fatigue within 12 weeks of starting intramuscular B12 injections

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