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Inhibition or depletion of GPX4 utilizing the chemical inhibitor RSL3 or specific siRNA resulted in lipid peroxide accumulation, leading to ferroptosis in H9C2 cells [87]

doi: 10.1007/BF02088746 160 ScheibeKKerstenCSchmiedAViethMPrimbsTCarlBet al

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Inhibition of GCS It is well known [27, 41] that GSH is a competitive inhibitor against glutamate of GCS, the enzyme that catalyzes the synthesis of glutamyl-cysteine

GPX4 in cell death, autophagy, and disease