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Description

Under normal conditions, NRF2 is recognized and ubiquitinated by the Keap1-Cul3 E3 ligase complex, marking it for proteasomal degradation and maintaining its low levels in the cell

A notable example is vitamin C (ascorbic acid) and its stable derivative, L-ascorbic acid 2-phosphate, which significantly enhance the proliferative capacity and effector functions of T cells, a unique subset of T lymphocytes that bridge innate and adaptive immunity