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Most flavones of vegetables and fruits has a hydroxyl group in position 5 of the A ring, while the hydroxylation in other positions, for the most part in position 7 of the A ring or 3 and 4 of the B ring may vary according to the taxonomic classification of the particular vegetable or fruit

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TLR4, for example, activates intracellular signaling via the MyD88 adaptor protein, leading to NF-B activation and subsequent transcription of pro-inflammatory cytokines (TNF-, IL-1, IL-6), chemokines (CCL2, CXCL10), and other mediators [444]

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Typically it recognises gluten and gliaden as harmless, however in Coeliac individuals, gliaden is marked as a pathogen, therefore inciting an immune response thus damaging the small intestine