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Studies using rat brain mitochondria have shown that safinamide exhibits 5,000 times greater selectivity for MAO-B over MAO-A, compared to the more modest selectivity ratios of 127 times for selegiline and 103 times for rasagiline [82]

Indeed, a common outcome in plants subjected to environmental constraint (e.g., salinity, drought, cold, heavy metals, pathogens) is an enhanced level of ROS and MG, which have deleterious effects on multiple classes of biomolecules

Probiotics may also have potential risks for patients with immunodeficiency as opportunistic pathogens (Doron and Snydman, 2015)

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Illicit drug residues have been found in river basins, surface waters, and wastewaters, with inadequately-treated municipal wastewater discharge, cited as the main vector of contamination (101)