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Vitamin B12 is water-soluble, meaning excess amounts are excreted through urine, reducing the risk of toxicity

However, the key limitations of existing studies lie in small clinical sample sizes without multicenter validation and unstandardized intervention protocols in animal models, both of which impede clinical translation

(2018) remains the most comprehensive single source, but it is animal work [1]

They are involved in hemostasis, angiogenesis, inflammation, neural tube closure, and cell growth [86]

Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction