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In diet-induced obesity models: These findings suggest that the compounds effects are driven by metabolic reprogramming rather than appetite suppression, making it highly relevant for research into lipid metabolism and energy utilization

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On the other hand, oral supplements are processed through the digestive system, which might slow down absorption and the onset of benefits

Conversely, removing polyphenols and proteins from some sources, such as edible mushroom polysaccharides, markedly reduces their antioxidant potential (140)

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