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For details, refer to: Government explains isolation and quarantine arrangement for COVID-19 cases and close contacts involving sub-lineages of Omicron mutant strain In response to media enquiries, a Government spokesman said that Hong Kong has all along been implementing a five-tier arrangement for isolation of local cases tested positive for the SARS-CoV-2 virus and where appropriate quarantine of their close contacts at home or designated facilities since the fifth wave epidemic that started in end 2021

Sci Rep (2016) 6:29914

One ligand interacts with the protein of interest (POI) while the other one recruits an E3 ubiquitin ligase, mostly CRBN (Cereblon) or VHL (Von Hippel-Lindau) (Chirnomas et al, 2023

doi: 10.1016/j.cmet.2024.01.005

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