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When you train or rehabilitate after injury, IGF-1 signaling engages satellite cells, boosts translational capacity, and coordinates extracellular matrix remodeling steps required to enlarge existing fibers and support new myofiber formation

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Investigators have also noted that the pronounced appetite-stimulating effect of MK-677 an on-target consequence of ghrelin receptor agonism in hypothalamic appetite circuits complicates body composition endpoints in metabolic studies, as caloric intake must be carefully controlled to isolate GH-axis-mediated changes from orexigenic-driven weight gain

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