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No controlled study has confirmed the frequency or severity of the effect in humans

in 2024 reported from Spain the antiaging effects of custom low-molecular-weight collagen peptide supplementation (2.5 g) on facial wrinkles and skin hydration in a 6-week randomized, double-blind, placebo-controlled trial [46]

Studies should also be carried out on several patients to establish a therapeutic dose, mode of administration, optimal targets, and even the need to administer other antioxidants simultaneously with VIC [52]

Common observations include a reduction in certain beneficial genera (such as butyrate producers Roseburia and Faecalibacterium ) and an increase in pro-inflammatory genera (like Escherichia or Oscillospira in some reports) [213]

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