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However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

Phosphorylation of Ser307 in insulin receptor Substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

Indeed, subjects with reduced absolute neutrophil counts are more prone to repeated infections while uncontrolled/abnormal neutrophil function may lead to tissue damage and associated autoimmune disorders [33]

4.2 Small molecule inhibitors targeting NNMT In addition to RNAi drugs, the development of small molecule inhibitors targeting NNMT represents a current research focus for the treatment of MetS-related diseases

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