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Because of the presence of APAP in numerous prescription and over-the-counter medications, intentional and unintentional overdosing occurs regularly

10.1016/j.jpsychires.2008.01.010 91

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However, this ERK5 destabilization is quantitatively and kinetically much less efficient than the targeted, proximity-induced degradation achieved by the bifunctional ERK5-CHAMP (HLE, RNK06138) with differences in DC 50 and Dmax potencies (Fig

Meanwhile, the metabolomic analysis revealed that MOX-Cu mainly affected amino acid-associated metabolic pathways, including glutathione metabolism, arginine biosynthesis, and purine metabolism, which were closely associated with redox regulation and energy homeostasis (Figs