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2A and 2B) despite varied basal levels (Fig

FDA Registration Number: 70-1-18565-5-0336

The therapeutic effects of antidepressants consist in the increased function of the noradrenergic or serotonergic system, leading to increased activity of transcription factor CREB (cAMP response element binding protein), higher expression of neurotrophin BDNF and its receptor trkB, and consequently to increased neuronal plasticity and resumption of cellular functions