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However, excess ROS induces inflammatory cell infiltration and macrophage polarization through mitochondrial homeostasis disruption and production of pro-inflammatory factors, forming a vicious cycle of central nerve inflammation and ROS production, further aggravating inflammation and the formation of glial cell scar

It is currently being investigated in phase 3 trials, and results from a phase 2 trial published in the New England Journal of Medicine are show great promise

The data of gene expression profiling have been uploaded to the NCBI Gene Expression Omnibus under accession number GSE152537

This could be as simple as a vitamin deficiency, or a complication of diabetes

doi: 10.1080/21691401.2019.1607362 196 QuSPLiGWMaHXingQ