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The synthetic analog replicates a 15-amino acid sequence and has been studied for its potential to influence fibroblast activity, angiogenesis, nitric oxide pathway regulation, and extracellular matrix remodeling across experimental models

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BMJ Open, 10 (8), e033687

In human studies, long-term recreational ketamine use has been associated with structural brain changes, including reduced prefrontal gray matter volume and impaired white matter connectivity, which are potentially linked to chronic low-grade inflammation (Liao et al., 2011