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NAC, in particular, has been shown to increase glutathione levels in the liver and other tissues (1)

The liver generally oxidises xenobiotics and produces glucuronic acid, sulfate or glutathione conjugates

Binding to antioxidant response elements (AREs) induces the transcription of genes regulated by AREs, which initiates the expression of genes encoding cytoprotective enzymes, such as antioxidative stress proteins, especially antioxidant enzymes ( Figure 2 The antioxidant response is also modulated by signaling pathways mediated by adenosine 5'-monophosphate-activated protein kinase (AMPK)

Redox modulation of the apoptogenic activity of thapsigargin

Glutathione, Oxidized (GSSG) is the oxidized version of the naturally occurring and very important antioxidant glutathione (GSH)