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17 Compounding the issue is the fact that various professional organizations and grading references (the American Academy of Pediatrics, American Family Practice, Scottish Intercollegiate Guidelines Network, and many others) have different letter assignments and cutoffs for the use of non-RCT-containing literature, creating confusion about the meaning of an A, B, or C to denote the quality of literature used for evidence

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In this study almost 60% of the patients who received the above combination experienced grade 3-4 irAEs